Compositions and methods for treating ophthalmic diseases

Details Compositions and methods for treating ophthalmic diseases Compositions and methods for treating ophthalmic diseases

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 38/12 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2716185

Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol corn-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed.

L'invention concerne des compositions polymériques dégradables contenant des médicaments insolubles dans l'eau mélangées à des copolymères de motifs monomériques de composé diphénolique biocompatible comprenant des groupes carboxyliques pendants polymérisées avec des motifs monomériques de composé diphénolique biocompatible comprenant des groupes ester d'acide carboxylique pendants et des séquences poly(alkylène oxyde), dans lesquels la fraction molaire dans le copolymère de motifs monomériques de composé diphénolique biocompatible comprenant des groupes ester d'acide carboxylique pendants et des séquences poly(alkylène oxyde) rapportée au pourcentage pondéral du médicament dans la composition est suffisante pour permettre une libération d'ordre pseudo-zéro du médicament par la composition pendant la phase de libération prolongée de délivrance du médicament dans des conditions physiologiques. L'invention concerne également des procédés de traitement oculaire et des procédés de fabrication.

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