C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2672297
Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein.
Cette invention concerne des composés, des compositions et des méthodes permettant d'empêcher la perméabilité vasculaire et l'angiogenèse pathologique. Sont également décrites de méthodes d'obtention et de criblage de compositions, pharmaceutiques notamment, capables d'inhiber la perméabilité vasculaire et l'angiogenèse. Ces compositions trouvent leur utilité avec des méthodes destinées à inhiber la perméabilité vasculaire et l'angiogenèse pathologique, notamment la perméabilité vasculaire et l'angiogenèse pathologique induite par des facteurs angiogenèse, de perméabilité et inflammatoires spécifiques tels que VRGF, bFGF et la thrombine. Sont également décrites des méthodes de traitement de maladies et d'états pathologiques spécifiques.
Jones Christopher
Li Dean
London Nyall
Ridout & Maybee Llp
University Of Utah Research Foundation
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