C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) C12N 5/071 (2010.01) A61K 35/28 (2006.01) A61K 35/34 (2006.01) A61K 35/44 (2006.01) A61P 9/10 (2006.01) C12N 5/00 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2679178
The invention relates to methods for producing endothelial cells, pericytes and/or muscle cells (in particular smooth muscle cells), cell preparations and pharmaceutical compositions comprising the cells or preparations, and the use of the cells, preparations and compositions in research or commercial applications. In aspects, the invention provides a method of treating a patient with a condition involving endothelial cells, endothelial precursor cells, pericytes and/or muscle cells, such as a peripheral vascular disease, comprising administering to the patient endothelial precursor cells, endothelial cells, pericytes and/or muscle cells obtained from multipotent CD45+HLA-ABC+Lin- cells.
La présente invention concerne des procédés permettant de produire des cellules endothéliales, des cellules de pericyte et/ou musculaires (en particulier des cellules de muscles lisses), des préparations cellulaires et des compositions pharmaceutiques comprenant ces cellules ou ces préparations, et l'utilisation de ces cellules, de ces préparations et de ces compositions dans des applications de recherche ou du commerce. Dans certains aspects, l'invention concerne un procédé de traitement d'un patient avec des cellules endothéliales, des cellules précurseurs endothéliales, des cellules de pericyte et/ou musculaires associées à un état pathologique, tel qu'une maladie vasculaire périphérique, qui consiste à administrer à ce patient ces cellules précurseurs endothéliales, ces cellules endothéliales, ces cellules de pericyte et/ou musculaires obtenues à partir de cellules CD45+HLA-ABC+Lin- multipotentes.
Bielecki Ryszard
Casper Robert
Rogers Ian
Mccarthy Tetrault Llp
Mount Sinai Hospital
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