C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 13/12 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12N 15/11 (2006.01) C12N 15/866 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2348563
The present invention provides an isolated antibody or fragment thereof that binds to an epitope present in the transmembrane domain of polycystin and specifically recognizes a polycystin-related polypeptide having an apparent molecular weight in the range of about 600 to about 800 kD. Polynucleotides, polypeptides, gene delivery vehicles and host cells containing the transmembrane sequences are also provided. Further provided are methods and compositions for modulating the biological activity of polycystin in a suitable cell or tissue.
L'invention concerne un anticorps isolé ou un fragment de celui-ci liant un épitote présent dans le domaine transmembranaire de la polycystine et reconnaît spécifiquement un polypeptide apparenté à la polycystine, ayant un poids moléculaire apparent compris entre environ 600 et environ 800 kD. L'invention concerne également des polynucléotides, des polypeptides, des véhicules distributeurs de gènes et des cellules hôtes contenant les séquences transmembranaires. L'invention concerne en outre des procédés et des compositions destinés à moduler l'activité biologique de la polycystine dans une cellule ou un tissu approprié.
Ibraghimov-Beskrovnaya Oxana
Petry Linda R.
Van-Dellen Katrina
Borden Ladner Gervais Llp
Genzyme Corporation
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