C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/519 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2495663
Fusion proteins comprising a Receptor for Advanced Glycation End Products Ligand Binding Element (RAGE-LBE) and an immunoglobulin element are disclosed. Also disclosed are fusion proteins comprising a RAGE-LBE and a dimerization domain. Also disclosed are nucleic acids encoding such fusion proteins and methods for using disclosed nucleic acids and proteins to, for example, treat RAGE-related disorders. Additional compositions and methods are also disclosed.
La présente invention concerne des protéines de fusion comprenant un élément de liaison aux ligands du récepteur de produits finaux de glycation avancée (RAGE-LBE) ainsi qu'un élément immunoglobuline. Cette invention concerne également des protéines de fusion comprenant un RAGE-LBE ainsi qu'un domaine de dimérisation. Cette invention concerne en outre des acides nucléiques codant ces protéines de fusion ainsi que des méthodes d'utilisation des acides nucléiques et protéines de la présente invention pour, notamment, traiter des troubles associés au récepteur RAGE. Cette invention concerne enfin d'autres compositions et méthodes.
Brennan Fionula Mary
Clancy Brian
Feldman Jeffrey L.
Feldmann Marc
Foxwell Brian John Maurice
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Imperial College Innovations Limited
Wyeth
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