C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01)
Patent
CA 2693553
The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
La présente invention porte sur des compositions pharmaceutiques et sur des procédés utiles pour moduler l'angiogenèse et inhiber une métastase, des tumeurs, une protéinose pulmonaire alvéolaire et une fibrose dans un tissu de mammifère. Les compositions pharmaceutiques et les procédés renferment des inhibiteurs de l'expression et de l'activité de LOXL2, tels que l'ARNsh ciblant LOXL2.
Integral Ip
Technion Research & Development Foundation Ltd.
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