A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01)
Patent
CA 2617161
Disclosed herein are methods of delaying the onset or treating diabetes that comprises administering a uric acid lowering agent. The inventors have made the remarkable discovery that elevated uric acid levels are not a corollary to insulin resistance, but rather a primary mediator of insulin resistance. Specifically exemplified are methods that involve administering to a patient susceptible to development of diabetes a composition comprising a uric acid lowering agent in a regimen that maintains serum uric acid levels below at least 5.5 mg/dl, or below at least 5.2 mg/dl.
La présente invention concerne des procédés, permettant de retarder l~apparition de diabètes ou de les traiter, qui consistent à administrer un agent diminuant l~acide urique. Selon l~invention, les niveaux élevés d~acide urique ne sont pas un corollaire à la résistance à l~insuline, mais plutôt un médiateur principal de cette résistance. Plus précisément, l~invention porte sur des procédés qui impliquent l~administration à un patient susceptible de développer un diabète d~une composition renfermant un agent diminuant l~acide urique selon un schéma posologique qui maintient les niveaux d~acide urique à des valeurs égales à au moins 5,5 mg/dl, ou inférieures à au moins 5,2 mg/dl.
Johnson Richard J.
Nakagawa Takahiko
Gowling Lafleur Henderson Llp
University Of Florida Research Foundation Inc.
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