A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7072 (2006.01) A61K 31/40 (2006.01)
Patent
CA 2538403
Compositions and methods for treatment of conditions related to the overexpression of EZH2, such as late stage prostate cancer, using a DNA methylation inhibitor and/or a histone deacetylase inhibitor, optionally in combination with an EZH2 antagonist and/or an antineoplastic agent, to specifically target diseases associated with EZH2 over~expression. Further provided are reagents and kits for treatment of EZH2 overexpression.
L'invention concerne des compositions et des méthodes de traitement de pathologiques associées à la surexpression de EZH2, notamment au cancer de la prostate en phase terminale, au moyen d'un inhibiteur de méthylation d'ADN et/ou d'un inhibiteur d'histone déacétylase éventuellement en combinaison avec un antagoniste EZH2 et/ou un agent antinéoplasique, et plus spécifiquement des maladies cibles associées à la surexpression EZH2. Font également l'objet de cette invention des réactifs et des kits de traitement de la surexpression EZH2.
Borden Ladner Gervais Llp
Supergen Inc.
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