C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2690782
The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyr.tau.oIidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyr.pi.>lidine-2,5-dione compound of the present invention. (Ia) (Ib) (IIa) (IIb) Where U is independently selected from: (I) or (II)
L'invention concerne des composés de pyrrolidine-2,5-dione, et des procédés de préparation de ces composés. La présente invention concerne également des compositions pharmaceutiques comprenant des composés de pyrrolidine-2,5-dione. La présente invention concerne des procédés de traitement de troubles liés à la prolifération cellulaire, tels qu'un cancer, par administration à un sujet en ayant besoin d'une quantité thérapeutiquement efficace d'un composé ou du composé de pyrrolidine-2,5-dione de la présente invention.
Ali Syed M.
Ashwell Mark A.
Hill Jason
Namdev Nivedita D.
Wang Jianqiang
Arqule Inc.
Mcfadden Fincham
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