C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/46 (2006.01) A61K 31/357 (2006.01) A61P 9/00 (2006.01) C07D 405/02 (2006.01)
Patent
CA 2759821
Ortho methoxy phenolic compounds are provided that include methylenedioxyphenyl ferulate and ferulylproline and derivatives thereof. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease, angina, stroke, and myocardial infarction, are further provided. The compounds are also useful in reducing low-density lipoprotein oxidation, improving or increasing vasodilation, and reducing plaque destabilization in a subject.
L'invention concerne des composes ortho-méthoxyphénoliques, qui comprennent le ferulate de méthylènedioxyphényle et la ferulylproline, et leurs dérivés. L'invention concerne également, des compositions pharmaceutiques comprenant les composés et des procédés d'utilisation des composés pour traiter des maladies cardiovasculaires, comprenant l'hypertension, l'athérosclérose, une maladie coronarienne, l'angine de poitrine, l'attaque et l'infarctus du myocarde. Les composés sont utiles pour réduire l'oxydation des lipoprotéines de faible densité, améliorer ou accroître la vasodilatation et réduire la déstabilisation de la plaque chez un sujet.
Invasc Therapeutics Inc.
Moffat & Co.
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