A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7088 (2006.01) A61K 31/575 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2674683
We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N- terminal sequence that is not found in the IBABP protein. The present invention provides, for example, compositions and methods for diagnosing and treating colorectal cancer.
L'invention concerne l'identification d'une nouvelle variante de la protéine de liaison aux acides biliaires iléaux (IBABP), désignée par IBABP-L, qui est un biomarqueur du cancer colorectal. Le produit de la transcription de l'IBABP-L provient d'un autre site de démarrage et comprend trois exons qui sont absents dans l'IBABP. L'IBABP-L partage aussi une partie d'un quatrième exon avec l'IBABP. La protéine codée par l'IBABP-L contient une séquence N-terminale réduite de 49 résidus qui n'est pas présente dans la protéine IBABP. La présente invention propose, par exemple, des compositions et des procédés permettant de diagnostiquer et de traiter un cancer colorectal.
Fang Changming
Smith Jeffrey W.
Smart & Biggar
The Burnham Institute For Medical Research
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