Compositions and methods for treatment of congestive heart...

Details Compositions and methods for treatment of congestive heart... Compositions and methods for treatment of congestive heart...

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) C07K 14/605 (2006.01)

Patent

CA 2652907

Provided herein is the use of GLP-1 molecules or agonists and analogs thereof, and the use of exendin molecules or agonists and analogs thereof, including their derivatives and active fragments, for the prevention or treatment of congestive heart failure. Pharmaceutical compositions for use in the methods described herein are also disclosed. Further provided are compositions and methods for the treatment and/or prevention of diabetes mellitus, hyperglycemia, insulin resistance and obesity, and for the reduction of food intake and suppression of appetite of subjects.

La présente invention concerne l'utilisation de molécules ou agonistes GLP-1 et d'analogues de ceux-ci, et l'utilisation de molécules ou agonistes d'exendine et d'analogues de ceux-ci, y compris leurs dérivés et fragments actifs, pour assurer la prévention ou le traitement de l'insuffisance cardiaque globale. L'invention concerne également des compositions pharmaceutiques destinées à être utilisées dans les procédés selon l'invention. L'invention concerne en outre des compositions et des procédés pour assurer le traitement et/ou la prévention du diabète sucré, de l'hyperglycémie, de la résistance à l'insuline et de l'obésité, et la réduction de prise alimentaire et la suppression d'appétit des sujets.

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