Compositions and methods for treatment of diabetes

Details Compositions and methods for treatment of diabetes Compositions and methods for treatment of diabetes

A - Human Necessities

61

K

A61K 38/03 (2006.01) A61K 38/16 (2006.01) A61K 38/28 (2006.01) A61P 3/08 (2006.01)

Patent

CA 2630586

The present invention relates to a composition comprising a peptide of the formula: (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2 wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid; n1 is 0-10; and n2 is 0-10; and derivatives thereof; and insulin. Complexes of insulin and the peptides, methods of dispersing multimeric insulin complexes and methods of regulating in vivo blood glucose levels, particularly in the treatment of diabetes are also described.

La présente invention concerne une préparation comprenant un peptide de formule : (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2 où Xaa est un acide aminé quelconque ; Xaa1 est un acide aminé hydrophobe ; n1 est compris entre 0 et 10 inclus ; et n2 est compris entre 0 et 10 inclus ; et des dérivés dudit peptide ; et l'insuline. La présente invention concerne également des complexes de l~insuline et des peptides, des méthodes de dispersion de complexes d'insuline polymères et des méthodes de régulation de glycémie sanguine in vivo, en particulier dans le traitement du diabète.

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