Compositions and methods for treatment of hemorrhage

A - Human Necessities – 61 – K

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Details

A61K 33/06 (2006.01) A61K 9/32 (2006.01) A61K 47/48 (2006.01) A61P 9/00 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2756941

Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.

La présente invention concerne des procédés de traitement de l'hémorragie, comprenant le diagnostic d'un ou de plusieurs vaisseaux hémorragiques ou potentiellement hémorragiques chez un patient et l'administration à un patient d'une quantité thérapeutiquement efficace d'une composition comprenant un composé provoquant la fermeture d'un vaisseau à une concentration comprise entre environ 0,1 % et environ 45 %. Le composé provoquant la fermeture du vaisseau peut comprendre un polymère doté de propriétés hydrophiles, comme le polyéthylène glycol (PEG). La composition peut également comprendre un ou plusieurs ingrédients actifs, tels qu'un modificateur du flux sanguin ayant le potentiel de former des liaisons ioniques avec l'agent provoquant la fermeture du vaisseau.

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