A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A01N 43/04 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2568750
The present invention provides compositions and methods of treating neovascular diseases, such as a retinal neovascular diseases and tumors, by administering to a patient suffering from a neovascular disease or tumor a vascular development inhibiting amount of a combination of the angiogenesis suppressing drugs comprising an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS) and at least one compound selected from the group consisting of a vascular endothelial growth factor (VEGF) signaling inhibitor and an integrin signaling inhibitor. Compositions for use in the methods include an admixture of an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS) and at least one of a vascular endothelial growth factor (VEGF) signaling inhibitor and an integrin signaling inhibitor, together with a pharmaceutically acceptable excipient.
La présente invention fournit des compositions et des méthodes pour traiter les maladies néovasculaires telles que les maladies néovasculaires rétiniennes et les tumeurs, en administrant au patient soufrant d~une maladie néovasculaire ou d~une tumeur une quantité d~inhibiteur de développement vasculaire d~une combinaison d~un inhibiteur d~angiogénèse contenant un fragment angiostatique d~une synthétase tryptophanyle-tRNA (TrpRS) et au moins un composé sélectionné dans le groupe comprenant un inhibiteur signalant un facteur de croissance endothéliale vasculaire (VEGF) et un inhibiteur signalant une intégrine. Les compositions à utiliser dans les méthodes incluent un fragment angiostatique d~une synthétase tryptophanyle-tRNA (TrpRS) et au moins un inhibiteur signalant un facteur de croissance endothéliale vasculaire (VEGF) et un inhibiteur signalant une intégrine, ainsi qu~un excipient acceptable d~un point de vue pharmaceutique.
Aguilar Hilda Edith
Dorrell Michael I.
Friedlander Martin
Cassan Maclean
The Scripps Research Institute
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