Compositions and methods for treatment of protein misfolding...

Details Compositions and methods for treatment of protein misfolding... Compositions and methods for treatment of protein misfolding...

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 1/107 (2006.01) C07K 7/06 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2583231

Small molecular weight molecules are provided including, but not limited to, peptides, peptide analogs and peptide mimetics that stabilize and prevent the aggregation of abnormally folded and compromised proteins. Methods for treatment of disease are provided utilizing the peptides, peptide analogs or peptide mimetics, or utilizing nucleic acids encoding the peptides.

L'invention concerne des molécules à faible poids moléculaire contenant de manière non exhaustive des peptides, des analogues peptidiques et des minétiques peptidiques qui stabilisent et préviennent l'aggrégation de protéines anormalement pliées et alétérées. L'invention concerne également des procédés de traitement de maladies utilisant des peptides, des analogues de peptide ou des mimétiques de peptide ou des acides nucléiques codants pour les peptides.

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