Compositions and methods for treatment of staphylococcal...

Details Compositions and methods for treatment of staphylococcal... Compositions and methods for treatment of staphylococcal...

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 31/00 (2006.01) A61K 31/43 (2006.01) A61K 31/48 (2006.01) A61K 31/545 (2006.01) A61K 45/06 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2362487

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include .beta.-lactams and glycopeptides.

L'invention concerne la co-administation de lysostaphine et d'un autre agent anti-staphilococcique qui produit un clivage des réticulations de peptidoglycans de parois cellulaires staphilococciques, telles que la lysostaphine et un antibiotique efficace contre les staphilocoques du fait de leur activité antibiotique induite par l'activité pariétale. Cette co-administration est efficace contre l'infection staphilococcique, y compris les staphilocoques pouvant être résistants à une lysostaphine ou à l'antibiotique actif sur la paroi. Cette co-administration élimine simultanément la production de souches mutantes résistantes aux antibiotiques. Parmi les antibiotiques actifs sur la paroi, on trouve les .beta.-lactames et les glycopeptides.

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