Compositions and methods for treatment of vitamin d deficiency

Details Compositions and methods for treatment of vitamin d deficiency Compositions and methods for treatment of vitamin d deficiency

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2473182

The present invention provides peptides which are characterized by having a biological activity that increases 25-hydroxyvitamin D3 1a-hydroxylase activity in a cell, thereby increasing calcitriol (active vitamin D) levels. The peptides have a sequence related to the contiguous sequence defined by residues 242 to 264 in the naturally occurring matrix extracellular phosphoglycoprotein (PHEX). Methods of modulating 25-hydroxyvitamin 1a- hydroxylase gene expression and calcitriol levels using the subject peptides are also provided. Also provided are kits for practicing the subject methods. The subject compositions and methods find use in a variety of application, including the treatment of vitamin D-related disorders, such as Paget's Disease, rickets, osteoporosis, renal osteodystrophy, and psoriasis.

L'invention concerne des peptides caractérisés par leur activité biologique en ce qu'elle permet d'augmenter l'activité de la 25-hydroxyvitamine D3 1a-hydrolase dans une cellule, augementant ainsi les taux de calcitriol (forme active de la vitamine D). Les peptides possèdent une séquence en rapport à la séquence contigue définie par les résidus 242 à 264 de la phosphoglycoprotéine (PHEX) extracellulaire naturelle de la matrice. L'invention concerne aussi des procédés de modulation de l'expression du gène de la 25-hydroxyvitamine D3 1a-hydrolase et des taux de calcitriol au moyen des peptides de l'invention. Elle concerne enfin des kits de mise en oeuvre des procédés concernés. Les composition et les procédés de l'invention s'utilisent dans de nombreuses applications, en particulier dans le traitement de troubles associés à la vitamine D, tels que la maladie de Piaget, le rachitisme, l'ostéoporose, l'ostéo-dystrophie rénale et le psoriasis.

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