Compositions and methods for use in targeting vascular...

Details Compositions and methods for use in targeting vascular... Compositions and methods for use in targeting vascular...

C - Chemistry, Metallurgy

07

F

C07F 9/12 (2006.01) A61K 31/455 (2006.01) A61K 31/495 (2006.01) A61K 31/661 (2006.01) A61K 31/6615 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2455956

Treatment of warm-blooded animals having a tumor or non-malignant hypervascularization, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity far microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.

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