A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7076 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2531062
Methods and compositions including combined use of a serine protease inhibitor and adenosine when administered as a single pharmaceutical composition, concomitantly or sequentially in any order to a living subject for preventing organ ischemia or reperfusion injury. The methods and compositions disclosed herein can be used in such procedures as cardiac surgery, non-surgical cardiac revascularization, organ transplantation, perfusion, ischemia, reperfusion, ischemia-reperfusion injury, oxidant injury, cytokine induced injury, shock induced injury, resuscitations injury or apoptosis.
L'invention concerne des méthodes et des compositions combinant un inhibiteur de sérine protéase et une adénosine administrés dans une seule composition pharmaceutique, en même temps ou de manière séquentielle, et dans n'importe quel ordre, à un sujet vivant dans la prévention d'une ischémie organique ou d'une lésion de reperfusion. Les méthodes et compositions de l'invention peuvent être utilisées dans des interventions telles que la chirurgie cardiaque, la revascularisation cardiaque non chirurgicale, la transplantation d'organes, la perfusion, l'ischémie, la reperfusion, les lésions d'ischémie-reperfusion, les lésions d'oxydation, des lésions induites par une cytokine, des lésions induites par un choc, des lésions de réanimation ou l'apoptose.
Emory University
Gowling Lafleur Henderson Llp
LandOfFree
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