Compositions and methods for using stromal cells to enhance...

A - Human Necessities – 61 – K

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A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61K 47/26 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2753833

The present invention provides novel methods and compositions for the treatment of injuries to the mammalian central nervous system. These methods involve administering stromal cells in combination with a blood-brain barrier permeabilizing agent in order to enhance neurorestoration, functional neurological recovery, stromal cell engraftment, and treatment of neurodegenerative diseases.

La présente invention concerne de nouvelles méthodes et compositions pour le traitement de blessures au système nerveux central de mammifères. Ces méthodes comportent ladministration de cellules stromales en association avec un agent de perméabilisation de la barrière hémato-encéphalique pour améliorer la neurorestauration, la récupération neurologique fonctionnelle, la prise de greffe des cellules stromales et le traitement de maladies neurodégénératives.

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