A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 9/127 (2006.01) A61K 39/395 (2006.01) A61L 15/44 (2006.01) A61P 17/02 (2006.01)
Patent
CA 2693219
The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osetoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked a-gal epitopes for induction of an inflammatory response localized within or surrounding damaged tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects.
L'invention concerne le domaine de la cicatrisation des plaies ou de la régénération tissulaire suite à une maladie (par exemple des maladies cardiovasculaires, des maladies ostéoarthritiques, ou des diabètes). En particulier, la présente invention fournit des compositions et des procédés comprenant des molécules avec des épitopes a-gal liés pour l'induction d'une réponse inflammatoire localisée dans ou autour du tissu abîmé. Dans certains modes de réalisation, la présente invention fournit des traitements pour une réparation tissulaire chez des sujets normaux et chez des sujets ayant des capacités de guérison altérées, comme des sujets diabétiques et âgés.
Galili Uri
Smart & Biggar
University Of Massachusetts Medical School
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