Compositions and methods for wt1 specific immunotherapy

Details Compositions and methods for wt1 specific immunotherapy Compositions and methods for wt1 specific immunotherapy

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2465303

Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

L'invention concerne des compositions et des procédés pour la thérapie de maladies malignes, telles que la leucémie et le cancer. Ces compositions comprennent au moins un polynucléotide WT1, un polypeptide WT1, une cellule présentatrice de l'antigène présentant un polypeptide WT1, un anticorps qui se lie spécifiquement à un polypeptide WT1, ou une cellule T qui réagit spécifiquement à un polypeptide WT1. De telles compositions peuvent être utilisées, par exemple, pour la prévention et le traitement de maladies métastatiques.

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