Compositions and methods for wt1 specific immunotherapy

Details Compositions and methods for wt1 specific immunotherapy Compositions and methods for wt1 specific immunotherapy

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 38/16 (2006.01)

Patent

CA 2523943

ABSTRACT OF THE DISCLOSURE Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

L'invention concerne des compositions et des procédés destinés à la thérapie de maladies malignes telles que la leucémie et le cancer. Lesdites compositions contiennent un polynucléotide WT1 et/ou un polypeptide WT1 et/ou une cellule présentant un antigène, présentant un polypeptide WT1 et/ou un anticorps se liant spécifiquement à un polypeptide WT1 et/ou une cellule T réagissant spécifiquement avec un polypeptide WT1. De telles compositions peuvent par exemple être employées dans la prévention ou le traitement de maladies métastatiques.

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