Compositions and methods for wt1 specific immunotherapy

Details Compositions and methods for wt1 specific immunotherapy Compositions and methods for wt1 specific immunotherapy

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2349442

Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

Cette invention a trait à des compositions et aux méthodes thérapeutiques en rapport dirigées contre des affections malignes, telles que la leucémie et le cancer. Ces compositions renferment un ou plusieurs polynucléotides du WT1, un polypeptide du WT1, une cellule présentatrice d'antigène présentant un polypeptide du WT1, un anticorps se fixant de manière spécifique à un polypeptide du WT1 ou un lymphocyte T réagissant de manière spécifique avec un polypeptide du WT1. Il est possible d'utiliser ces compositions aux fins de la prévention et du traitement de maladies métastatiques.

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