A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 47/44 (2006.01) A61L 2/16 (2006.01) A61L 2/18 (2006.01) A61L 12/14 (2006.01)
Patent
CA 2269764
The present invention is directed to an ophthalmically safe disinfecting solution for contact lenses comprising a bis(biguanide) having formula (I) wherein R1 and R4 are independently selected from the group consisting of branched or unbranched alkyl having 4-12 carbon atoms, ether or thioether radical having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl radical having 5-12 carbon atoms; R2 and R3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1- 12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12 carbon atoms; R6 and R7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is selected from the divalent radical having 4-16 carbon atoms consisting of a divalent alkyl, alkyloxyalkyl, alkylsulfide, or a polymethylene interrupted with a cyclic divalent radical. In one embodiment of the present invention, such biguanides may be combined with a polymeric biguanide for complementary or synergistic biocidal efficacy. The invention is also directed to an improved method of disinfecting a contact lens.
Cette invention concerne une solution désinfectante pour lentilles de contact qui ne présente pas de risques sur le plan ophtalmologique, et qui comprend un bis(guanide) correspondant à la formule (I) où R?1¿ et R?4¿ sont choisis indépendamment dans le groupe comprenant les éléments suivants: un alkyle ramifié ou non ramifié comportant de 4 à 12 atomes de carbone, un radical éther ou thioéther comportant de 4 à 12 atomes de carbone, ou un radical cycloalkyle ou cycloalkyl-alkyle comportant de 5 à 12 atomes de carbone. R?2¿ et R?3¿ sont indépendamment choisis dans le groupe comprenant les éléments suivants: hydrogène, alkyle comportant de 1 à 12 atomes de carbone, alcoxyalkyle comportant de 1 à 12 atomes de carbone, ou cycloalkyle ou cycloalkyl-alkyle comportant de 5 à 12 atomes de carbone. R?6¿ et R?7¿ sont quant à eux choisis dans le groupe comprenant hydrogène et un radical alkyle comportant de 1 à 6 atomes de carbone. A est choisi à partir d'un radical divalent qui comprend de 4 à 16 atomes de carbone et qui consiste en un alkyle, un alkyloxyalkyle ou un alkylsulfure divalents ou, encore, en un polyméthylène interrompu par un radical divalent cyclique. Dans un mode de réalisation, ces biguanides peuvent être combinés à un biguanide polymère afin d'obtenir une efficacité biocide additionnelle ou synergique. Cette invention concerne également un procédé amélioré de désinfection de lentilles de contact.
Heiler David J.
Marsh David A.
Simpson Lisa C.
Spooner Susan P.
Bausch & Lomb Incorporated
Osler Hoskin & Harcourt Llp
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