C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/31 (2006.01) A01N 63/02 (2006.01) A01P 1/00 (2006.01) C07K 14/01 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) C12N 15/31 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2433308
The invention relates to bacterial genes and proteins that are implicated in the process of fatty acid/phospholipid biosynthesis and also to bacteriophage genes and their protein products that interact with bacterial proteins implicated in fatty acid/phospholipid biosynthesis. More particularly, the invention relates to compositions and methods involving essential Staphylococcus aureus genes and its encoded proteins STAAU_R4. In addition, the invention relates to screening assays to identify compounds which modulate the level and/or activity of STAAU_R4 and to such compounds.
L'invention concerne des gènes bactériens et des protéines bactériennes impliqués dans le processus de biosynthèse d'acide gras/phospholipide, ainsi que des gènes du bactériophage et les produits protéiques associés interagissant avec des protéines bactériennes impliquées dans une biosynthèse d'acide gras/phospholipide. Plus précisément, l'invention concerne des compositions et des méthodes mettant en oeuvre des gènes essentiels de <i>Staphylococcus aureus</i> et les protéines codées STAAU R4 associées. De plus, l'invention concerne des analyses de balayage permettant d'identifier des composés modulant le niveau et/ou l'activité des protéines STAAU R4, ainsi que de tels composés.
Dubow Michael
Gros Philippe
Pelletier Jerry
Fasken Martineau Dumoulin Llp
Phagetech Inc.
Targanta Therapeutics Inc.
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