C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/04 (2006.01) A61K 39/085 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) C12P 21/00 (2006.01) C12Q 1/18 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2433386
The invention relates to bacterial genes and proteins that are implicated in the process of DNA replication and also to bacteriophage genes and their protein products that interact with bacterial proteins involved in DNA replication. The invention also relates to antibacterial agents, compositions and methods for inhibiting bacterial growth, and more particularly for inhibiting primase DnaG activity in Staphylococcus aureus. In addition, the invention relates to screening assays to identify novel antibacterial agents binding to Staphylococcus aureus DnaG primase.
L'invention concerne des gènes bactériens et des protéines bactériennes impliqués dans le processus de réplication de l'ADN, ainsi que des gènes du bactériophage et les produits protéiques associés interagissant avec des protéines bactériennes impliquées dans une réplication de l'ADN. Plus précisément, l'invention concerne des compositions et des méthodes mettant en oeuvre un gène essentiel de <i>Staphylococcus aureus</i> et la protéine codée STAAU R9 associée. De plus, l'invention concerne des analyses de balayage permettant d'identifier des composés modulant le niveau et/ou l'activité de la protéine STAAU R9, ainsi que de tels composés.
Bergeron Dominique
Dubow Michael
Gros Philippe
Pelletier Jerry
Fasken Martineau Dumoulin Llp
Phagetech Inc.
Targanta Therapeutics Inc.
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