C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A01N 63/02 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/085 (2006.01) A61P 31/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/31 (2006.01) C12Q 1/02 (2006.01) C12Q 1/34 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2396674
This invention relates to newly identified polynucleotides and polypeptides, their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylococcus aureus (S. aureus) DnaI related protein, as well as its variants. Also, the invention relates to a specific interaction between the S. aureus DnaI related protein or specific regions thereof, and a growth-inhibitory protein encoded by the S. aureus bacteriophage 77 genome. The phage protein interacts with amino acids 150 - 313 of S. aureus DnaI polypeptide, and the invention relates to the use of this interaction target site as the basis of drug screening assays. In addition, the invention relates to polynu- cleotides and polypeptides of a protein complex containing S. aureus DnaI and DnaC related proteins, as well as their variants.
La présente invention concerne des polynucléotides et des polypeptides nouvellement identifiés, leurs production et utilisations, ainsi que leurs variants, agonistes et antagonistes, et leurs utilisations. Notamment, cette invention concerne des polynucléotides et des polypeptides d'une protéine afférente d'ADNi de Staphylococcus aureus</i> ( S. aureus ), ainsi que ses variants. En outre, cette invention a trait à une interaction spécifique entre la protéine afférente d'ADNi de <i>(S. aureus) ou des régions spécifiques correspondantes et une protéine inhibitrice de croissance codée par le génome du bactériophage 77 de ( S. aureus ). La protéine de bactériophages interagit avec des acides aminés 150 313 du polypeptide d'ADNi de (S aureus) , et l'invention concerne l'utilisation de ce site cible d'interaction en tant que base de dosages de criblage de médicaments. Par ailleurs, cette invention concerne des polynucléotides et des polypeptides d'un complexe protéique contenant des protéines afférentes d'ADNc et d'ADNi de (S. aureus) , ainsi que leurs variants.
Dubow Michael
Gros Philippe
Pelletier Jerry
Fasken Martineau Dumoulin Llp
Phagetech Inc.
Targanta Therapeutics Inc.
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