Compositions and methods of delivering bleaching agents to...

A - Human Necessities – 61 – K

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A61K 8/22 (2006.01) A61K 8/02 (2006.01) A61K 8/38 (2006.01) A61K 8/72 (2006.01)

Patent

CA 2550724

The present invention relates to compositions and methods of whitening teeth of a subject in need thereof, by applying a safe and effective amount of a composition to a plurality of teeth, the composition comprising: a. a safe and effective amount of a bleaching agent; b. a safe and effective amount of a water insoluble solid phase; c. a safe and effective amount of a water soluble liquid phase; wherein the ratio of the water insoluble solid phase to water soluble liquid phase is from about 1:4 to about 4:1; wherein the composition is applied for a sufficient period of time to achieve whitening; and wherein in one embodiment the composition has a Whitening Index of from about 0.5 to about 4. The composition comprises a hydrophobically modified polymer. The present invention also relates to a delivery system comprising the present compositions used with an integral carrier, e.g. a strip material, dental tray or sponge material.

La présente invention concerne des compositions et des procédés pour blanchir les dents d'un sujet par l'application à une pluralité de dents d'une quantité inoffensive et efficace d'une composition de blanchiment, la composition comprenant: a) une quantité inoffensive et efficace d'un agent de blanchiment; b) une quantité inoffensive et efficace d'une phase solide insoluble dans l'eau; et c) une quantité inoffensive et efficace d'une phase liquide hydrosoluble. Le rapport entre la phase solide insoluble dans l'eau et la phase liquide soluble dans l'eau est comprise entre environ 1:4 et environ 4:1, la composition étant appliquée pendant une période de temps suffisante pour effectuer le blanchiment. Dans un mode de réalisation, la composition a un indice de blanchiment entre environ 0,5 et environ 4. La composition comprend un polymère modifié de manière hydrophobe. La présente invention concerne aussi un système d'administration comprenant les présentes compositions utilisées avec un support intégral tel qu'un matériau en forme de bande, un plateau dentaire ou une matière spongieuse.

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