Compositions and methods of detecting tiabs

Details Compositions and methods of detecting tiabs Compositions and methods of detecting tiabs

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 5/0783 (2010.01) C07K 16/18 (2006.01) C07K 17/00 (2006.01) C12N 15/12 (2006.01) C40B 30/04 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2709130

The present invention relates to novel methods and products for assessing the physiological status of a subject. More particularly, the invention relates to methods of assessing the presence, risk or stage of a cancer in a subject by measuring the levels of antibodies against particular aberrant protein domains in a sample from the subject, or the presence or number of immune cells bearing TCR specific for such aberrant protein domains. The invention is also suitable to assess the responsiveness of a subject to a treatment, as well as to screen candidate drugs and design novel therapies. The invention may be used in any mammalian subject, particularly in human subjects.

La présente invention concerne de nouveaux procédés et produits pour évaluer l'état physiologique d'un sujet. Plus particulièrement, l'invention concerne des procédés permettant d'évaluer la présence, le risque ou le stade d'un cancer chez un sujet en mesurant les taux d'anticorps dirigés contre des domaines particuliers de protéines aberrantes dans un échantillon du sujet. Ils permettent également d'évaluer la présence ou le nombre de cellules immunes porteuses de TCR pour de tels domaines de protéines aberrantes. L'invention est également appropriée pour évaluer la faculté de réponse d'un sujet à un traitement, ainsi que pour cribler des médicaments candidats et concevoir de nouvelles thérapies. L'invention peut être utilisée chez tout mammifère, plus particulièrement chez des sujets humains.

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