Compositions and methods of enhancing immune responses to...

A - Human Necessities – 61 – K

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A61K 39/012 (2006.01) A61K 35/74 (2006.01) A61K 39/00 (2006.01) A61P 33/02 (2006.01) A61P 37/04 (2006.01) A61K 39/112 (2006.01)

Patent

CA 2704422

Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

L'invention concerne des vaccins comportant des polypeptides TRAP et des vecteurs de Salmonella enteritidis comportant de polypeptides TRAP. Les vaccins peuvent également comprendre un polypeptide CD 154 capable de se lier au CD4Q. Il est également proposé des procédés d'amplification d'une réponse immunitaire à des parasites d'apicomplexes et des procédés de réduction de la morbidité associée à l'infection par des parasites d'apicomplexes.

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