A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/365 (2006.01) A61K 31/16 (2006.01) A61K 31/197 (2006.01) A61K 31/27 (2006.01)
Patent
CA 2711957
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effective to alleviate conditions associated with a reduced concentration of PEA. Among other uses, various NAAA inhibitors are especially contemplated as therapeutic agents in the treatment of inflammatory diseases.
Cette invention concerne des composés et des compositions pharmaceutiques qui inhibent l'amidase acide d'hydrolyse de la n-acyléthanolamine (NAAA) de manière à augmenter la concentration du substrat de NAAA, le palmitoyléthanolamide (PEA). L'inhibition de NAAA est censée être efficace pour soulager les affections associées avec une concentration réduite en PEA. Entre autres utilisations, différents inhibiteurs de NAAA sont envisagés en particulier comme agents thérapeutiques dans le traitement des maladies inflammatoires.
Duranti Andrea
Mor Marco
Piomelli Daniele
Tarzia Giorgio
Tontini Andrea
Miltons Ip/p.i.
The Regents Of The University Of California
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