Compositions and methods of producing hybrid antigen binding...

Details Compositions and methods of producing hybrid antigen binding... Compositions and methods of producing hybrid antigen binding...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) C07K 14/575 (2006.01) C07K 14/59 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2627446

This disclosure relates to hybrid antigen binding molecules including at least two polypeptide chains, with at least one polypeptide chain comprises an antigen binding moiety linked to an amino acid sequence of a subunit of a heterodimeric proteinaceous hormone. Also disclosed are methods of making and using such hybrid antigen binding molecules for diagnosis and/or therapy.

L'invention porte sur des molécules hybrides se fixant à des antigènes et comportant au moins deux chaînes de polypeptides dont l'une au moins comprend un fragment se fixant à un antigène lié à la séquence d'acide aminé d'une sous-unité d'une hormone protéique hétérodimère. L'invention porte également sur des méthodes de production et d'utilisation de ces molécules hybrides à des fins diagnostiques ou thérapeutiques.

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