C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2691510
The invention features a method for treating cancer by administering a double- stranded nucleic acid molecule against a CX gene selected from the group consisting of C14orf78, MYBL2, UBE2S and UBE2T. The invention also features products, including the double-stranded nucleic acid molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods. The methods of the invention are suited for the treatment of cancers including lung cancer, breast cancer, bladder cancer, esophagus cancer, prostate cancer, cholangiocellular carcinoma and testicular seminoma.
La présente invention concerne un procédé permettant de traiter le cancer par l'administration d'une molécule d'acide nucléique double brin sur un gène CX sélectionné parmi le groupe comprenant C14orf78, MYBL2, UBE2S et UBE2T. L'invention concerne également des produits, notamment les molécules d'acide nucléique double brin et des vecteurs codant pour elles, ainsi que des compositions contenant les molécules ou les vecteurs, qui se révèlent utiles pour les procédés revendiqués. Les procédés de l'invention sont appropriés au traitement de cancers, notamment le cancer du poumon, le cancer du sein, le cancer de la vessie, le cancer de l'sophage, le cancer de la prostate, le carcinome cholangiocellulaire et le séminome testiculaire.
Ishizaki Yuka
Konuma Akiko
Tobita Ryutaro
Togashi Akira
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
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