Compositions and methods of treatment of sympathetically...

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/155 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/475 (2006.01) A61K 31/48 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2104873

Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an .alpha.-1-adrenergic antagonist, .alpha.-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic nor-epinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

La douleur sympathique est traitée localement par administration sur le site de manifestations de la douleur sympathique un antagoniste alpha-1-adrénergique, un agoniste alpha-2-adrénergique ou une autre substance médicamenteuse qui affaiblit ou inhibe la synthèse de la norépinéphrine sympathique. Ces substances étant désignées collectivement agents sympatholytiques. Les formules chimiques de plusieurs agents sympatholitiques sont données.

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