Compositions and methods of use for antibodies of c-met

Details Compositions and methods of use for antibodies of c-met Compositions and methods of use for antibodies of c-met

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2646048

Antibodies and fragments that bind to the protein target c Met, particularly to epitopes located in the c Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c Met-related condition such as a cancer, a metastasis, or an inflammatory condition.

La présente invention concerne des anticorps et des fragments qui se lient à la protéine cible c-Met, particulièrement aux épitopes positionnés dans le domaine extracellulaire de c-Met. L'invention concerne également des procédés d'utilisation des anticorps et des trousses, destinés au traitement d'une cellule indésirable, en particulier, d'une cellule associée à une pathologie liée à c-Met telle qu'un cancer, une métastase, ou un état inflammatoire.

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