Compositions and methods of use for therapeutic antibodies

Details Compositions and methods of use for therapeutic antibodies Compositions and methods of use for therapeutic antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2730063

Antibodies that specifically bind to the BAFF receptor (BAFFR). More specifically antibodies that are BAFFR an-tagonists with in vivo B cell depleting activity and compositions and methods of use for said antibodies to treat pathological disor-ders that can be treated by killing or depleting B cells, such as systemic lupus erythematosus or rheumatoid arthritis or other au-toimmune diseases or lymphomas, leukemias and myelomas.

L'invention porte sur des anticorps qui se lient de façon spécifique au récepteur BAFF (BAFFR). Plus spécifiquement, l'invention porte sur des anticorps qui sont des antagonistes de BAFFR avec une activité de déplétion des cellules B in vivo, et sur des compositions et procédés d'utilisation pour lesdits anticorps pour traiter des troubles pathologiques qui peuvent être traités par destruction ou déplétion des cellules B, tels que le lupus érythémateux systémique ou la polyarthrite rhumatoïde ou dautres maladies auto-immunes, des lymphomes, des leucémies ou des myélomes.

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