C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/078 (2010.01) C12N 5/0793 (2010.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 38/06 (2006.01)
Patent
CA 2232262
Methods and compositions for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal are disclosed. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory tissue, such as dermis or at least one nerve segment, and are subsequently administered into the central nervous system of a mammal at or near a site of injury or disease. In an alternative embodiment, autologous monocytes, preferably stimulated autologous monocytes, are administered into the central nervous system of a mammal at or near a site of injury or disease. Methods for identifying stimulatory tissue and cells and methods and compositions for cryopreserved allogeneic mononuclear phagocytes are also disclosed.
Ces procédés et compositions permettent d'utiliser des phagocytes mononucléaires allogènes pour promouvoir la régénération axonale dans le système nerveux central d'un mammifère. Dans une variante, on cultive ces phagocytes mononucléaires allogènes avec des tissus stimulants, comme le derme ou un segment de nerf au moins, puis on les administre dans le système nerveux central d'un mammifère, à l'endroit d'une blessure ou maladie ou à proximité. Dans une autre variante, on administre des monocytes antologues, de préférence stimulés, dans le système nerveux central, d'un mammifère, à l'endroit d'une blessure ou maladie ou à proximité. On décrit aussi des procédés permettant d'identifier des cellules et tissus stimulants, et des procédés et compositions relatifs à des phagocytes mononucléaires allogènes cryoconservés.
Eisenbach-Schwartz Michal
Hirschberg David L.
Spiegler Orly
Osler Hoskin & Harcourt Llp
Yeda Research And Development Co. Ltd.
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