Compositions and methods of use of orf 554 from beta...

Details Compositions and methods of use of orf 554 from beta... Compositions and methods of use of orf 554 from beta...

A - Human Necessities

61

K

A61K 39/09 (2006.01) A61P 31/04 (2006.01) C07K 14/315 (2006.01)

Patent

CA 2728258

The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polypeptides and polynucleotides, as well as antibodies and antibody fragments that bind the PPI polypeptides. In addition, the invention relates to methods of inducing an immune response in a subject against beta hemolytic streptococci using the immunogenic compositions, as well as conferring passive immunity by administering a therapeutic antibody or antibody fragment.

L'invention concerne des compositions et des procédés d'utilisation de polypeptides peptidylprolyl isomérase (PPI) de streptocoques des groupes C et G, et de polynucléotides codant lesdits polypeptides. L'invention concerne également des compositions immunogènes comprenant lesdits polynucléotides et polypeptides PPI, ainsi que des anticorps et des fragments d'anticorps qui se lient aux polypeptides PPI. En outre, l'invention concerne des procédés destinés à induire, chez un patient, une réponse immunitaire dirigée contre des streptocoques bêta-hémolytiques à l'aide de compositions immunogènes, et à conférer une immunité passive par administration d'un anticorps ou d'un fragment d'anticorps thérapeutique.

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