G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/864 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2496938
The present invention concerns compositions comprising and methods of identification and use of targeting peptides selective for cancer tissue, particularly prostate or ovarian cancer tissue. The method may comprise identifying endogenous mimeotopes of such peptides, such as GRP78, IL- 11R.alpha. and hsp90. Antibodies against such targeting peptides or their mimeotopes may be used for detection, diagnosis and/or staging of prostate or ovarian cancer. In other embodiments, the compositions and methods concern novel type of gene therapy vector, known as adeno-associated phage (AAP). AAP are of use for targeted delivery of therapeutic agents to particular tissues, organs or cell types, such as prostate or ovarian cancer. In still other embodiments, targeting peptides selective for low-grade lipomas may be used for detection, diagnosis and targeted delivery of therapeutic agents.
L'invention concerne des compositions et des procédés d'identification et d'utilisation de peptides de ciblage sélectifs pour les tissus cancéreux, en particulier de la prostate ou de l'ovaire. Le procédé peut consister à identifier des mimotopes endogènes de ces peptides, tels que GRP78, IL-11R.alpha. et hsp90. Des anticorps contre ces peptides de ciblage ou leurs mimotopes peuvent servir à la détection, au diagnostic et/ou à la stadification du cancer de la prostate ou de l'ovaire. Dans d'autres modes de réalisation, les compositions et procédés portent sur un nouveau type de vecteur de thérapie génique, appelé phage associé aux adénovirus (AAP). Les AAP conviennent pour l'administration ciblée d'agents thérapeutiques à des tissus, des organes ou des types cellulaires particuliers, par exemple les cancers de la prostate ou de l'ovaire. Dans d'autres modes de réalisation encore, les peptides de ciblage sélectifs pour des lipomes bénins peuvent faciliter la détection, le diagnostic et l'administration ciblée d'agents thérapeutiques.
Arap Wadih
Kolonin Mikhail G.
Mintz Paul J.
Pasqualini Renata
Zurita Amado J.
Board Of Regents The University Of Texas System
Goudreau Gage Dubuc
LandOfFree
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