C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 9/12 (2006.01) C12P 21/02 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2544807
The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.
La présente invention concerne, d'une part l'acide nucléique d'une kinase en relation avec la kinase de signalisation de l'apoptose ou "ASKRK" (Apoptosis Signaling Kinase Related Kinase) ainsi que des séquences de polypeptides, et d'autre part des procédés permettant d'utiliser de telles séquences pour identifier des modulateurs de l'ASKRK. De tels modulateurs conviennent au traitement du diabète, mais également pour retarder l'apparition du diabète. L'invention concerne enfin des procédés permettant de diagnostiquer des états diabétiques ou pré-diabétiques, ainsi que des procédés permettant de faire un pronostic sur la base de la détection des acides nucléiques et des protéines de l'ASKRK
Johnson Jeffrey D.
Marlen Kimberly
Zhou Yun-Ping
Fetherstonhaugh & Co.
Metabolex Inc.
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