Compositions and methods of using capsid protein from...

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 38/16 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/40 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/79 (2006.01) C12N 15/85 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2424216

This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions WNV or encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or ant- Flavivirus and/or anti-Pestivirus capside or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.

La présente invention concerne des procédés qui permettent d'induire la mort des cellules à l'aide d'une protéine de capside de <i>Flavivirus </i>ou de <i>Pestivirus</i>, telle que la protéine de capside du virus de West Nile virus (WNV) et des fragments fonctionnels de cette dernière; des procédés de traitement de patients atteints de maladies se caractérisant par des cellules hyperprolifératives au moyen de l'administration de compositions pharmaceutiques contenant WNV ou d'autres virus comprenant la capside de <i>Flavivirus </i>ou de <i>Pestivirus </i>ou une autre protéine ou une autre molécule d'acide nucléique codant cette dernière; des procédés d'identification de composés ayant une capside antivirale et/ou anti-WNV et/ou anti-<i>Flavivirus</i> et/ou anti-<i>Pestivirus</i> ou une autre activité de protéine; des compositions vaccinales comprenant la capside ou les protéines, ou des fragments de ces dernières, ou encore des acides nucléiques codant ces dernières, provenant du WNV ou d'un autre virus tel que le <i>Flavivirus</i> ou le <i>Pestivirus</i> et un support pharmaceutiquement acceptable; des procédés de diagnostic et des trousses permettant d'identifier les individus exposés au WNV ou à d'autres virus tels que le <i>Flavivirus</i> ou le <i>Pestivirus</i>.

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