Compositions and methods of using chondroitinase abci mutants

Details Compositions and methods of using chondroitinase abci mutants Compositions and methods of using chondroitinase abci mutants

A - Human Necessities

61

K

A61K 38/47 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2623635

One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

Un aspect de la présente invention se rapporta à des mutants des chontroïtinases ABCI. Ces mutants font preuve d'une modification de l'activité lyase de la chondroïtine ou d'une résistance accrue à l'inactivation initiée par des stresseurs, y compris à l'exposition aux UV ou à la chaleur. L'invention concerne également des procédés d'utilisation de ces enzymes.

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