Compositions and methods of using chondroitinase abci mutants

Details Compositions and methods of using chondroitinase abci mutants Compositions and methods of using chondroitinase abci mutants

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) A61K 38/51 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2666536

The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

La présente invention concerne des mutants de protéines et d'acides nucléiques de la chondroïtinase ABCI. De telles enzymes mutantes de la chondroïtinase ABCI montrent une modification de l'activité de lyase de la chondroïtine ou une résistance accrue à l'inactivation initiée par des stresseurs, y compris à l'exposition aux UV ou à la chaleur. L'invention porte sur des procédés d'utilisation des enzymes mutantes de la chondroïtinase ABCI.

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