Compositions and methods related to claudin-7

A - Human Necessities – 61 – K

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A61K 39/17 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2378608

This invention provides for methods of modulating angiogenesis and/or endothelial cell proliferation. In particular, applications of reducing or inhibiting angiogenesis, tumor growth, endothelial proliferation by the administration of compositions containing Claudin-7 and biological equivalents thereof. The invention also relates to compositions and methods for treatment for disorders associated with angiogeneis (e.g., cancer).

L'invention concerne des procédés permettant de moduler l'angiogénèse et/ou la prolifération cellulaire endothéliale, en particulier, des applications visant à réduire ou à inhiber l'angiogénèse, la croissance tumorale et la prolifération endothéliale par administration de compositions contenant claudine-7 et ses équivalents biologiques. L'invention porte également sur des compositions et procédés destinés au traitement de troubles associés à l'angiogénèse (par exemple le cancer).

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