Compositions and methods related to controlled gene...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/63 (2006.01) A01K 67/027 (2006.01) A61K 39/00 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) C12P 21/02 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2633442

Provided herein are methods and compositions relating to viral vectors. Also provided herein are methods and compositions for the efficient transfection of a host, for example through the highly efficient lentivector delivery system, and for the exquisite control of the timing and level of expression of the transferred sequence of interest by the simple administration of a modulator to the host harboring the transferred sequence of interest. Also disclosed are methods of making transgenic mice and transgenic mice made using compositions and methods relating to viral vectors.

L'invention concerne des procédés et des compositions se rapportant à des vecteurs viraux. Elle concerne également des procédés et compositions destinés à la transfection efficace d'un hôte, par exemple, via un système hautement efficace de lentivecteur, et à un contrôle précis de la temporisation et du taux d'expression de la séquence d'intérêt transférée par une simple administration d'un modulateur à l'hôte comprenant la séquence d'intérêt transférée. L'invention concerne également des procédés pour fabriquer des souris transgéniques et des souris transgéniques fabriquées au moyen de ces compositions ainsi que des procédés se rapportant aux vecteurs viraux.

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