Compositions and methods related to mrna translational...

Details Compositions and methods related to mrna translational... Compositions and methods related to mrna translational...

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2708766

Provided are mRNA translational enhancer elements (TEEs), e.g., SEQ ID NOs: 1-35. Also provided are translational enhancer polynucleotides that comprise one or more of the specific TEEs exemplified herein or their variants, homologs or functional derivatives. Further provided are expression vectors comprising such TEEs or translational enhancer polynucleotides, as well as host cells and expression systems that harbor such vectors.

L'invention concerne des éléments activateurs de traduction de l'ARNm (TEE), par exemple, SEQ ID No.: 1-35. Des polynucléotides activateurs de traduction qui comprennent un ou plusieurs des TEE spécifiques représentés dans la présente ou leurs variants, homologues ou dérivés fonctionnels sont également proposés. L'invention propose, en outre, des vecteurs d'expression comprenant ces TEE ou polynucléotides activateurs de traduction, ainsi que des cellules hôtes et des systèmes d'expression hébergeant ces vecteurs.

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