Compositions and methods related to nitrotyrosine-containing...

Details Compositions and methods related to nitrotyrosine-containing... Compositions and methods related to nitrotyrosine-containing...

C - Chemistry, Metallurgy

12

N

C12N 5/0783 (2010.01) A61K 31/198 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/44 (2006.01) C12N 5/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2453387

Herein, it is demonstrated that the posttranslational modification of the amino acid tyrosine to nitrotyrosine has profound consequences for immune recognition. Furthermore, it is demonstrated that self-proteins containing nitrotyrosine can be recognized by the immune systems as foreign and as such these same proteins can be converted to potential autoantigens. As such, this invention relates to compositions and methods for the prevention, diagnosis and treatment of conditions including autoimmune diseases, infectious diseases and cancer through the recognition of compounds containing nitrated tyrosine residues.

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