Compositions and methods related to protein a (spa) variants

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/31 (2006.01) A61K 39/085 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2757543

Disclosed are methods and compositions for treating or preventing a Staphylococcus bacterial infection using a non-toxigenic Protein A (SpA) variant.

La présente invention concerne des méthodes et des compositions destinées au traitement ou à la prévention d'une infection bactérienne, notamment une infection à une bactérie Staphylococcus. L'invention concerne des méthodes et des compositions permettant de stimuler une réponse immunitaire contre les bactéries. Dans certains modes de réalisation, les méthodes et les compositions mettent en jeu un variant de la protéine A (SpA) non toxicogénique.

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